Nicotinamide

Nicotinamide (Niacinamide)

Description:

Pharmaceutical-grade Nicotinamide (Vitamin B3) for brightening, sebum control, and barrier repair.

CAS 98-92-0. Cosmetic, dietary, and clinical applications. Basic Information

• Chemical Name: Nicotinamide (Pyridine-3-carboxamide)

• Molecular Formula: C₆H₆N₂O

• CAS Number: 98-92-0

• Appearance: White crystalline powder

• Purity: ≥99.5% (HPLC)

• Solubility: Water-soluble (1g/1mL), stable in pH 3-10 formulations

• Storage: 15-25°C in airtight containers, protected from humidity

Product Description

Nicotinamide (Niacinamide), the bioactive form of Vitamin B3, is a versatile cosmeceutical and nutraceutical ingredient with proven efficacy in melanogenesis inhibition, sebum regulation, and NAD+/NADH coenzyme metabolism.

Our USP-grade material meets EP/JP standards, optimized for:

• Skincare: Non-irritating alternative to retinoids (effective at 2-5%)

• Pharma: Adjunct therapy for acne vulgaris and hyperpigmentation

• Supplements: Cellular energy support and DNA repair

Key Functions & Benefits

1. Skin Barrier Enhancement • Increases ceramide synthesis by 24% (in vivo studies) • Reduces TEWL (transepidermal water loss) by 38% in compromised skin

2. Pigmentation Control • Inhibits melanosome transfer to keratinocytes (43% reduction vs. placebo) • Addresses post-inflammatory hyperpigmentation and melasma

3. Anti-Aging & Texture Improvement • Boosts collagen Type I production via TGF-β pathway activation • Minimizes pore appearance through sebum normalization

4. Acne & Sebum Management • Reduces facial sebum excretion rate by 27% (12-week clinical trial) • Suppresses C. acnes-induced inflammation via IL-6/IL-8 modulation

Applications

1. Cosmeceuticals • Brightening serums: 4-5% with arbutin/glabridin for synergistic depigmenting • Moisturizers: 2% niacinamide + panthenol for barrier repair • Acne treatments: 5% gel formulations with zinc PCA

2. Nutraceuticals • NAD+ precursor in longevity supplements (300-500mg/day) • Combines with resveratrol for mitochondrial biogenesis

3. Pharmaceutical • Topical: 4% gel for moderate acne (FDA-approved) • Oral: 1500mg/day for non-melanoma skin cancer prevention 4. Hair Care • Scalp serums for dandruff control (inhibits Malassezia) • Heat protectant sprays to reduce protein oxidation