Factory Provide Cosmetic Grade Peptides Acetyl Tetrapeptide-2
Acetyl Tetrapeptide-2
Acetyl Tetrapeptide-2 (Peptigravity™ / Uplevity™)
Product Overview
Acetyl Tetrapeptide-2 (INCI name), also known as Peptigravity™ or Uplevity™, is a synthetic biomimetic tetrapeptide composed of four amino acids: lysine, aspartic acid, valine, and tyrosine. The N-terminal acetylation enhances its stability, solubility, and skin penetration. Functioning as a signal peptide, it mimics the activity of thymopoietin—a naturally occurring hormone in the body—and targets key structural proteins in the dermis to restore skin firmness, elasticity, and structural integrity. It is frequently referred to as the “gravity peptide” for its ability to counteract skin sagging and gravitational ptosis.
Chemical & Physical Specifications
Parameter | Specification |
|---|---|
INCI Name | Acetyl Tetrapeptide-2 |
CAS No. | 757942-88-4 |
Molecular Formula | C₂₆H₃₉N₅O₉ |
Molecular Weight | 565.6 – 565.62 g/mol |
Amino Acid Sequence | Ac-Lys-Asp-Val-Tyr-OH (Ac-KDVY) |
IUPAC Name | (2S,5S,8S,11S)-11-(4-Aminobutyl)-8-(carboxymethyl)-2-(4-hydroxybenzyl)-5-isopropyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazatetradecanoic acid |
Appearance | White to off-white crystalline powder; also available as clear liquid solution |
Purity (HPLC) | ≥ 95% – ≥ 99% (cosmetic grade ≥ 98% typical) |
Water Content (K.F.) | < 7.0% |
Acetate Content | < 15.0% |
Density | 1.3 ± 0.1 g/cm³ |
Boiling Point | 1015.0 ± 65.0 °C at 760 mmHg |
Flash Point | 567.6 ± 34.3 °C |
LogP | 0.31 |
Hydrogen Bond Donor Count | 8 |
Hydrogen Bond Acceptor Count | 10 |
Isoelectric Point (pI) | 7.05 |
Solubility | Soluble in water (>5 mg/mL); insoluble in oil |
InChI Key | ITIMHIATVYROGF-XWUOBKMESA-N |
Canonical SMILES | CC(C)C(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCCCN)NC(=O)C |
Heavy Metals | Compliant with global cosmetic standards |
Specifications may vary slightly by manufacturer; always request a Certificate of Analysis (COA) for each batch.
Key Benefits
Benefit Category | Description |
|---|---|
Anti-Gravity & Firming | Counteracts skin sagging and gravitational ptosis; provides lifted appearance and facial contour reshaping |
Collagen Stimulation | Stimulates Type I collagen synthesis (up to 47.3% increase reported); upregulates COL17A1 gene expression |
Elastin Enhancement | Promotes elastin production (up to 21.7% increase); upregulates FBLN5 and LOXL1 for functional elastic fiber assembly |
ECM Adhesion | Enhances cell-ECM adhesion via integrin and laminin pathways; improves dermal-epidermal junction (DEJ) cohesion |
Anti-Wrinkle | Reduces fine lines and wrinkles by restoring dermal structural integrity |
Anti-Inflammatory | Boosts skin immune defenses; reduces pro-inflammatory cytokines via NF-κB pathway inhibition |
Depigmenting | Inhibits tyrosinase activity, reducing melanin synthesis and brown spots |
Skin Barrier Support | Promotes keratinocyte proliferation; strengthens epidermal barrier function; reduces TEWL |
Hair Growth Support | Increases interfollicular keratinocyte proliferation; reduces TNF-alpha expression to prolong anagen phase |
Skin Conditioning | Provides soothing, nourishing, and plumping effects |
Clinical Data Reference: A double-blind trial showed that a formulation containing 0.05% Acetyl Tetrapeptide-2 improved skin elasticity by 19% and reduced wrinkle depth by 14% after 8 weeks of use.
Applications & Usage Guidelines
Recommended Applications:
Category | Specific Products |
|---|---|
Facial Care | Firming serums and creams, anti-aging formulations, eye contour creams/serums, uniforming serums, lotions, gels, SPF creams |
Body Care | Stretch mark creams, body firming milks |
Hair Care | Shampoos, conditioners (acute telogen effluvium/hair loss support) |
Post-Procedure | After-care for laser, RF, microneedling (collagen activation stage) |
Recommended Concentration:
Form | Recommended Dosage in Final Formulation |
|---|---|
Powder (≥98% purity) | 100 – 1000 ppm (0.01% – 0.1%) |
Powder (typical anti-aging) | 0.01% – 0.05% (100 – 500 ppm) |
Pre-diluted solution (0.1% active) | 1% – 10% |
Uplevity™ peptide solution | 1% – 2% (99.49% natural origin) |
Maximum historical use (China IECIC) | Leave-on products: 4%; Eye area leave-on: 2% |
The typical effective concentration range in finished cosmetic formulations is 0.01%–0.1% (100–1000 ppm). For skin firming applications, concentrations of 0.05%–0.1% are recommended. For sensitive skin formulations, lower concentrations (0.01%–0.02%) are suitable as a starting point.
Formulation Guidelines
pH Stability: Stable within pH range of 3.0–7.0. For maximum stability, maintain pH between 5.5 and 7.0. Avoid strongly acidic (pH < 4.0) or strongly alkaline (pH > 8.0) environments, which may cause peptide hydrolysis.
Thermal Stability: Heat sensitive. Add during the cooling phase at temperatures below 40°C (104°F). Avoid prolonged exposure to temperatures exceeding 45°C.
Solubility: Soluble in water (>5 mg/mL) and DMSO; insoluble in oil. For uniform distribution, pre-dissolve the peptide powder in a small amount of distilled water, propylene glycol, or butylene glycol at room temperature before adding to the main batch.
Formulation Compatibility:
Compatible with most cosmetic bases including serums, creams, lotions, gels, and emulsion systems
Compatible with other peptides (e.g., Palmitoyl Tripeptide-1, Acetyl Hexapeptide-8) for synergistic multi-target collagen stimulation
Compatible with vitamin C derivatives (AA2G), niacinamide, ceramides, panthenol (vitamin B5), centella asiatica (madecassoside) extract for enhanced barrier repair
Compatible with antioxidants (ergothioneine, ferulic acid) for enhanced photoprotection
Addition Protocol:
Pre-dissolve the peptide in a small amount of cool distilled water or suitable solvent (propylene glycol/butylene glycol) at room temperature
Ensure the main batch temperature is below 40°C before addition
Add the pre-dissolved solution slowly while stirring gently
Avoid high-shear mixing during or after peptide addition
Verify final formulation pH using a calibrated pH meter; adjust if necessary using mild pH modifiers within the optimal range
Incompatible Ingredients:
Ingredient | Reason |
|---|---|
High-concentration AHAs/BHAs (glycolic acid, salicylic acid) | Highly acidic; may cause peptide degradation |
Strong bases (pH > 8.0) | Alkaline conditions may cause peptide hydrolysis |
High concentrations of metal ions (iron, copper) | May catalyze oxidative reactions |
Strong oxidizing agents | May cause oxidative degradation of the peptide |
High-concentration EDTA/strong chelators | May interfere with peptide stability |