Cosmetic Grade Raw Material Acetyl hexapeptide-8
Acetyl hexapeptide-8
Acetyl Hexapeptide-8
Product Overview
Acetyl Hexapeptide-8 (INCI name), also known as Argireline® or Acetyl Hexapeptide-3, is a synthetic biomimetic peptide composed of six amino acids: arginine, methionine, glutamine, and acetylated glutamic acid residues. It is widely recognized as the first anti-wrinkle hexapeptide with a Botox®-like mechanism of action, offering a non-invasive topical solution for reducing expression lines and dynamic wrinkles.
The peptide works by mimicking the N-terminal end of the SNAP-25 protein, competitively inhibiting the formation of the SNARE complex. This prevents the fusion of synaptic vesicles with the neuronal membrane, thereby reducing the release of acetylcholine at the neuromuscular junction. The result is a temporary, partial blockade of neurotransmitter transmission, leading to muscle relaxation and reduced wrinkle formation without the adverse effects associated with botulinum toxin injections.
Acetyl Hexapeptide-8 has been cited by the Cosmetic Ingredient Review (CIR) in its safety assessment report and is listed in China‘s Inventory of Used Cosmetic Ingredients (IECIC), making it a globally accepted and trusted ingredient in anti-aging skincare formulations.
Chemical & Physical Specifications
Parameter | Specification |
|---|---|
INCI Name | Acetyl Hexapeptide-8 |
CAS No. | 616204-22-9 |
Molecular Formula | C₃₄H₆₀N₁₄O₁₂S |
Molecular Weight | 888.91 – 889.01 g/mol (typically 889.0) |
Peptide Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂ |
Appearance | White to off-white crystalline powder |
Purity (HPLC) | ≥ 95.0% – 98.0% (powder form); typical commercial ≥ 98.0% |
Water Content (K.F.) | ≤ 7.0% – 8.0% |
Acetate Content | ≤ 15.0% |
Total Plate Count | < 100 cfu/g |
Solubility | Soluble in water (>5 mg/mL), alcohol, and acetone; insoluble in glycerin |
pH (1% solution) | 3.0 – 6.0 (optimal stability range) |
Heavy Metals | Compliant with cosmetic safety standards |
Specifications may vary slightly by manufacturer; always request a Certificate of Analysis (COA) for each batch.
Mechanism of Action
Acetyl Hexapeptide-8 exerts its anti-wrinkle effect through a neurotransmitter-inhibiting mechanism. It competitively binds to the SNARE complex, interfering with the release of acetylcholine from nerve endings at the neuromuscular junction. By locally blocking the transmission of muscle contraction signals to the facial muscles, the peptide reduces muscle contractile activity, softening expression lines and preventing the formation of new dynamic wrinkles. This mechanism is similar to that of botulinum toxin but is non-toxic, reversible, and suitable for topical cosmetic use.
Clinical studies have demonstrated that Acetyl Hexapeptide-8 reduces wrinkle depth by up to 30% after 30 days of use, compared to a 10% reduction in control groups.
Applications & Usage Guidelines
Recommended Use: Anti-aging creams, serums, eye contour treatments, facial masks, toners, lotions, and emulsion gels.
Recommended Concentration:
Powder form: 50 – 500 ppm (0.005% – 0.05%) in finished formulations
Liquid solution (500 ppm): 3% – 10% in finished formulations
Key Benefits:
Reduces the appearance of expression lines and dynamic wrinkles (crow‘s feet, forehead lines, glabellar lines)
Promotes a relaxed facial appearance without affecting natural expressiveness
Softens existing fine lines and prevents new wrinkle formation
Non-toxic, non-irritating, and suitable for long-term use
Compatible with a wide range of cosmetic formulations
Formulation Compatibility:
Soluble in water, making it suitable for aqueous and emulsion systems
Stable at pH 3.0 – 6.0; avoid formulations with pH > 7.0, which may lead to peptide hydrolysis over long-term storage
Compatible with most cosmetic bases, including serums, creams, and gels
Avoid combining with strong oxidizing agents
Regulatory Status:
Listed in China‘s Inventory of Used Cosmetic Ingredients (IECIC), No. 07780
Cited by CIR (Cosmetic Ingredient Review) in its safety assessment report
EWG Skin Deep rating: Allowed for use in EWG VERIFIED products with use restrictions
Maximum safe use levels per China NMPA: Whole body leave-on 20%, whole body rinse-off 30%, eye leave-on 11%, eye rinse-off 14.95%
Certified: COSMOS, KOSHER, HALAL, REACH (varies by manufacturer)
Produced within GMP standard environments
Storage & Handling
Parameter | Condition |
|---|---|
Short-term storage | 2 – 8°C (refrigerator), sealed, protected from light |
Long-term storage | -20°C (freezer), tightly sealed, dry, and dark |
Shelf life | 24 months from date of manufacturing under recommended conditions |
Stability | Stable at pH 3.0 – 6.0; optimal at pH 5.0 |
Store the container tightly closed in a cool, dry place. Avoid exposure to strong oxidizing agents. For extended shelf life, maintain at -20°C. Protect from light and moisture.
Synonyms & Trade Names
Argireline®
Acetyl Hexapeptide-3
Anti-Wrinkle Hexapeptide
Peptidox P
INST-500 Amplified Solution
SpecPed® AH8-PS
ActiTide AH3
MacPeptide™ AH8
YouthFlex™
Packaging & Ordering Information
Parameter | Details |
|---|---|
Available package sizes | 5 mg, 10 mg, 50 mg, 100 mg, 500 mg, 1 g, 5 g, 10 g, 20 g, 25 g, 100 g, 500 g, 1 kg, 5 kg, 10 kg |
Standard packaging | Sealed foil bag or HDPE container with desiccant; liquid solutions available in bottles |
Minimum order quantity (MOQ) | 1 g (research grade); custom quantities available |
Certifications | COA, MSDS available upon request; GMP-compliant manufacturing |
Safety & Regulatory Information
Hazard classification: Not classified as a hazardous substance under GHS
Skin irritation: Non-irritating at recommended use levels; no skin or eye irritation observed
Heavy metals: Compliant with cosmetic safety standards
Toxicology: Low acute toxicity (oral/dermal); no genotoxicity or reproductive/developmental toxicity concerns at cosmetic use levels
Storage precautions: Avoid contact with oxidizing agents; use with adequate ventilation
Regulatory compliance: Refer to local regulations for specific compliance requirements; consult with a regulatory specialist for your target market
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