Cosmetic Grade Peptide Powder Dipeptide diaminobutyryl benzylamide diacetic acid
Dipeptide diaminobutyryl benzylamide diacetic acid
Dipeptide Diaminobutyryl Benzylamide Diacetate
Product Overview
Dipeptide Diaminobutyryl Benzylamide Diacetate (also known as SYN®-AKE, Snake Tripeptide, or Tripeptide-3) is a synthetic biomimetic tripeptide that mimics the mechanism of action of Waglerin-1, a neuroactive peptide found in the venom of the Temple Viper (Tropidolaemus wagleri). This ingredient acts as a reversible antagonist of the muscle nicotinic acetylcholine receptor (mnAChR), competitively binding to the ε-subunit of the receptor and blocking acetylcholine binding. This results in reduced muscle contraction, offering an effective, non-invasive solution for relaxing expression lines and preventing dynamic wrinkles.
The peptide is listed in China's Inventory of Used Cosmetic Ingredients (IECIC) and has been widely adopted in anti-aging skincare formulations, including serums, creams, eye contours, and facial masks, as a topical alternative to injectable neurotoxins.
Chemical & Physical Specifications
Parameter | Specification |
|---|---|
INCI Name | Dipeptide Diaminobutyroyl Benzylamide Diacetate |
CAS No. | 823202-99-9 |
Related CAS (free base) | 823202-98-8 |
Molecular Formula | C₁₉H₂₉N₅O₃ · 2(C₂H₄O₂) (or C₂₃H₃₇N₅O₇) |
Molecular Weight | 495.57 – 495.58 g/mol (diacetate salt) |
Purity (HPLC) | ≥ 98.0% (powder form); ≥ 95.0% also available |
Appearance | White to off-white crystalline powder |
Sequence | H-β-Ala-Pro-Dab-NH-Bzl (β-Ala-Pro-Dab-NHBn) |
PubChem CID | 71465152 |
InChI Key | HSUGRPOJOBRRBK-SXBSVMRRSA-N |
Isomeric SMILES | |
Solubility | Water: >5 mg/mL; DMSO: 3.0 mg/mL; freely soluble in water |
pH (1% solution) | 4.5 – 6.5 |
Acetate Content | 5.0% – 12.0% |
Moisture Content | ≤ 8.0% |
Peptide Content | ≥ 80.0% |
Specifications may vary slightly by manufacturer; always request a Certificate of Analysis (COA) for each batch.
Storage & Handling
Parameter | Condition |
|---|---|
Short-term storage | 0 – 4°C, sealed, protected from light |
Long-term storage | -20°C, tightly sealed, dry, and dark |
Shelf life | 24 months under recommended conditions |
Stability | Stable at pH 5.0 – 7.0 |
Store the container tightly closed in a cool, dry place. Avoid exposure to strong oxidizing agents. For extended shelf life, maintain at -20°C.
Mechanism of Action
Dipeptide Diaminobutyroyl Benzylamide Diacetate acts on the postsynaptic membrane as a reversible antagonist of the muscle nicotinic acetylcholine receptor (mnAChR). It binds to the ε-subunit of the mnAChR, blocking acetylcholine (ACh) from binding to the receptor. This prevents sodium ion influx, halting depolarization and nerve excitation transmission, ultimately resulting in muscle relaxation and reduced dynamic wrinkle formation.
In vitro studies have shown that this peptide is a competitive antagonist at the mnAChR, effectively relaxing facial muscles without permanently impairing normal neuromuscular function.
Applications & Usage Guidelines
Recommended Use: Anti-aging creams, serums, eye contour treatments, facial masks, toners, lotions, and emulsion gels.
Recommended Concentration: 0.001% – 0.01% (10 – 100 ppm) in finished cosmetic formulations; typical commercial solutions range from 1% to 4% in carrier systems.
Key Benefits:
Reduces the appearance of expression lines and dynamic wrinkles
Promotes a relaxed facial appearance without affecting natural expressiveness
Immediate and lasting relaxation of mimic wrinkles
Smooths skin texture and provides anti-aging benefits
Non-toxic, non-irritating, and free from heavy metals
Formulation Compatibility:
Compatible with most cosmetic bases
Water-soluble, suitable for both aqueous and emulsion systems
Avoid combining with strong oxidizing agents
Stable in pH range 5.0 – 7.0
Regulatory Status:
Listed in China IECIC (Inventory of Existing Cosmetic Ingredients)
EWG Skin Deep rating: Low concern for cancer, allergies, and reproductive/developmental toxicity
Packaging & Ordering Information
Parameter | Details |
|---|---|
Available package sizes | 1 g, 10 g, 100 g, 500 g, 1 kg, 5 kg, 10 kg, 20 kg, 25 kg |
Standard packaging | Sealed foil bag or HDPE container with desiccant |
Minimum order quantity (MOQ) | 1 g (research grade); custom quantities available |
Certifications | COA, MSDS available upon request; GMP-compliant manufacturing |
Safety & Regulatory Information
Hazard classification: Not classified as a hazardous substance under GHS
Skin irritation: Non-irritating (no skin or eye irritation observed)
Heavy metals: Free from detectable heavy metals
Toxicology: Low acute toxicity (oral/dermal); no genotoxicity or reproductive/developmental toxicity concerns
Storage precautions: Avoid inhalation and contact with eyes; use with adequate ventilation
Synonyms & Trade Names
SYN®-AKE
Snake Tripeptide
Tripeptide-3
Syn-Ake Diacetate
H-β-Ala-Pro-Dab-NH-Bzl acetate
β-Alanyl-L-prolyl-2,4-diamino-N-(phenylmethyl)butanamide diacetate
See more peptides to following link: