Cosmetic Grade Anti-Wrinkle Peptides Powder Skin Care ArginineLysine Polypeptide
ArginineLysine Polypeptide
Arginine/Lysine Polypeptide
Product Overview
Arginine/Lysine Polypeptide (INCI name) is a synthetic biomimetic peptide composed of the essential cationic amino acids L-arginine (Arg) and L-lysine (Lys). It belongs to the class of oligopeptides, which are smaller peptide chains containing at least two but typically not more than twenty amino acids. The compound is available in two distinct structural forms in the cosmetics market, each with different chemical identities, CAS numbers, and molecular profiles:
Type I — Polymer (CAS 31014-78-5)
Parameter | Specification |
|---|---|
INCI Name | Arginine/Lysine Polypeptide |
CAS No. | 31014-78-5 |
Chem/IUPAC Name | L-Arginine, polymer with L-lysine |
COSING REF No. | 31988 |
Molecular Formula | C₁₂H₂₈N₆O₄ |
Molecular Weight | 320.39 g/mol |
Degree of Polymerization (DP) | 2 – 7 (oligopeptide range) |
Dry Extract Content | 40% (w/w) |
Appearance | White to off-white powder (solid); colorless to pale yellow liquid (solution form) |
Purity | ≥ 95.0% – 98.0% (cosmetic grade) |
Solubility | Water-soluble |
Preservative System | 0.1% sorbic acid (Peptiskin® solution formulation) |
pH (1% solution) | 4.0 – 6.0 (typical range for peptide stability) |
Natural Origin Index | 99.9% (ISO 16128) |
InChI Key | OGDDUPYYEQZVHV-KDDYFZQKSA-N |
InChI | 1S/C6H14N4O2.C6H14N2O2/c7-4(5(11)12)2-1-3-10-6(8)9;7-4-2-1-3-5(8)6(9)10/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);5H,1-4,7-8H2,(H,9,10)/t4-;5-/m00/s1 |
SMILES |
Type I — Polymer (CAS 31014-78-5): Collagen Protection & Matrix Reinforcement
The Type I polymer (L-arginine/L-lysine copolymer) exerts its anti-aging effects primarily through a dual mechanism targeting both the dermal and epidermal matrix:
Stimulation of Extracellular Matrix Proteins: The oligopeptide blend stimulates key extracellular matrix (ECM) proteins to restore skin firmness, elasticity, and hydration. By mimicking endogenous signaling peptides, the compound activates fibroblast activity, promoting the synthesis of collagen and other structural proteins.
Strengthening Matrix Architecture: The peptide supports collagen organization, elastic fiber integrity, and dermo-epidermal cohesion, resulting in a more resilient and structured skin architecture.
Collagen Protection: Arginine/Lysine Polypeptide helps offset substances within the skin that break down collagen, protecting the existing collagen network from degradation.
Anti-Glycation Activity: The peptide delays visible signs of aging by helping prevent collagen degradation and limiting glycation-induced cross-linking, which leads to skin rigidity and wrinkle formation. Glycation occurs when reducing sugars react with proteins, forming advanced glycation end products (AGEs) that cause collagen and elastin fibers to become rigid, cross-linked, and less functional.
Skin Conditioning: The compound acts as a skin conditioning agent, improving overall skin feel and texture.
Key Benefits
Benefit Category | Type I (Polymer) | Type II (Conotoxin Mimic) |
|---|---|---|
Anti-Wrinkle | Reduces fine lines and wrinkles through collagen protection and matrix reinforcement | Provides rapid and immediate anti-wrinkle effect through muscle relaxation |
Firming & Elasticity | Restores firmness, elasticity, and hydration by stimulating ECM proteins | Improves skin laxity by reducing muscle contractile forces |
Collagen Protection | Helps offset collagen breakdown; prevents glycation-induced cross-linking | Supports existing collagen by reducing mechanical stress from muscle contractions |
Skin Conditioning | Acts as a skin conditioning agent, improving texture and feel | N/A |
Natural Expression | N/A | Preserves natural facial movement (5% neuromuscular conduction retained) |
Suitable Skin Types | All skin types; particularly effective for mature skin showing signs of intrinsic aging | All skin types; particularly effective for dynamic wrinkles (expression lines) |
Onset of Action | Gradual; long-term cumulative effect | Rapid; visible effect within minutes to hours |
Additional Benefits for Type II (Conotoxin Mimic): Whitening effect and skin repair properties have also been reported for this form.
Regulatory & Clean Beauty Highlights (Peptiskin® — Type I):
PFAS-free and solvent-free production process
99.9% natural origin (ISO 16128)
COSMOS-certified
Vegan-suitable
Registered in Japan under directive 92/32/EEC (classified as a polymer, therefore not requiring ELINCS registration)
Applications & Usage Guidelines
Recommended Applications
Application Category | Specific Products |
|---|---|
Anti-Aging Face Care | Anti-aging serums, firming creams, daily moisturizers, facial masks, toners, lotions |
Eye Care | Eye creams, eye serums, eye gels, eye patches — targeting crow‘s feet and periorbital wrinkles |
Wrinkle Treatment | Targeted wrinkle-reducing formulas for forehead lines, glabellar lines (frown lines), and expression lines |
Sensitive Skin Care | Calming and soothing products for reactive skin |
Post-Procedure Care | Recovery products after laser, chemical peels, and microneedling |
Sun Care | After-sun repair products |
For Type II (Conotoxin Mimic), additional specific applications include:
Eye Care: Visibly removes eye wrinkles and crow‘s feet
Facial Treatment: Visibly removes wrinkles caused by muscle contractions on the forehead
Recommended Concentration
Form | Recommended Dosage in Final Formulation |
|---|---|
Type I (Polymer — Powder, ≥95% purity) | 0.5% – 3% |
Type I (Polymer — Peptiskin® solution, 40% dry extract) | 0.5% – 3% |
Type II (Conotoxin Mimic — Powder, ≥98% purity) | 25 – 100 ppm (0.0025% – 0.01%) |
Type II (CG ALP solution — 25 ppm) | As supplied |
Type II (CG ALP solution — 100 ppm) | As supplied |
Incompatible Ingredients:
Ingredient | Reason |
|---|---|
Strong acids (glycolic acid, salicylic acid, high-concentration L-ascorbic acid) | Highly acidic; pushes pH below stable range |
Strong bases (sodium hydroxide, triethanolamine at high concentrations) | Alkaline conditions may cause peptide hydrolysis |
EDTA disodium and other strong chelators | May interfere with peptide structure and reduce activity |
Strong oxidizing agents (high-concentration hydrogen peroxide, benzoyl peroxide) | May cause oxidative degradation of the peptide structure |
Direct light (UV exposure) | UV radiation may oxidize the peptide; add photoprotective agents (e.g., tocopherol) or use opaque/amber packaging |
Addition Protocol:
Pre-dissolve the peptide in a small amount of cool distilled water or suitable solvent (propylene glycol, butylene glycol) at room temperature
Ensure the main formulation batch temperature is below 45°C before addition
Add the pre-dissolved peptide solution slowly while stirring gently
Avoid high-shear mixing during or after peptide addition
Verify final formulation pH using a calibrated pH meter; adjust if necessary using mild pH modifiers (e.g., citric acid or sodium hydroxide solutions)
For powder form, dissolve completely before adding to the batch
For high-concentration Type II formulations (conotoxin mimic), the use of penetration enhancers (e.g., lecithin) may be required to optimize transdermal absorption
Formulation Considerations by Dosage Form
Dosage Form | Considerations |
|---|---|
Serums (water-based) | Ideal for both Type I and Type II; allows maximum peptide concentration and penetration |
Creams (O/W emulsions) | Suitable; ensure water phase incorporation and final pH within 5.5–7.0 |
Gels | Excellent for both forms; transparent gel formulations allow visual confirmation of stability |
Masks | Suitable; peptide should be added during the cooling phase |
Toners/Lotions | Suitable; ensures even distribution of active |
Eye creams | Particularly suitable for both forms; use at recommended concentrations and combine with other eye-specific actives |
Storage & Handling
Parameter | Condition |
|---|---|
Short-term storage (both types) | 2 – 8°C (refrigerator), sealed, protected from light, dry |
Long-term storage (both types) | -20°C (freezer), tightly sealed, dry, and dark |
Shelf life (powder — Type I) | 24 months under recommended conditions |
Shelf life (powder — Type II) | 24 months (2 years) at 2–8°C |
Shelf life (Peptiskin® solution — Type I) | As specified by manufacturer (typically 24 months) |
Transport temperature | Ambient temperature acceptable for short-term transport |
Protection | Protect from light, heat, moisture, and strong oxidizing agents |
Solution stability | Stock solutions should be stored aliquoted in tightly sealed vials and used within 1 month; avoid repeated freeze-thaw cycles |
Packaging & Ordering Information
Parameter | Details |
|---|---|
Available package sizes (Type I — Powder) | 1 g, 10 g, 100 g, 1 kg, and larger upon request |
Available package sizes (Type II — Powder) | 1 g, 5 g, 10 g, 20 g, 25 g, 100 g, 500 g, 1 kg, 5 kg, 10 kg, 20 kg, 25 kg |
Available forms (Type I) | Powder (≥95% purity) / Solution (Peptiskin® — 40% dry extract) |
Available forms (Type II) | Powder (≥98% purity) / Pre-dissolved solution (25 ppm, 100 ppm, or custom concentration) |
Standard packaging | Sealed foil bag or HDPE container with desiccant; solutions in amber glass or HDPE bottles |
Minimum order quantity (MOQ) | 1 g (research grade); custom quantities available for commercial orders |
Sample availability | Samples available upon request |
Certifications | COA (Certificate of Analysis), MSDS/SDS, TDS (Technical Data Sheet) available; GMP-compliant manufacturing |
Custom synthesis | Available upon request with agreed specifications |
Product codes | CG-CPP-005 (CongenPharma, Type II); Peptiskin® (Solabia, Type I); SpecPed® MCC21 (Spec-Chem Industry, Type II formulation) |